Reactant1 Reactant2 Product kForward kReverse Comment GAP 0 0 kd214 k200 Grb2 0 0 kd222 k200 Sos 0 0 kd224 k200 Ras-GDP 0 0 kd226 k200 Shc 0 0 kd231 k200 Grb2-Sos 0 0 kd230 k200 EGFRi 0 0 k60 kd60 EGFi 0 0 k61 kd61 (EGF-EGFRi*)2 0 0 k60 kd60 (EGF-EGFRi*)2-GAP 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-Grb2 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-Grb2-Sos 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-SHC 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-SHC* 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-SHC*-Grb2 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP 0 0 k60 kd60 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP 0 0 k60 kd60 ERK-PP phosphatase3 ERK-PP-phosphatase3 k56 kd56 ERK-P phosphatase3 ERK-PP-phosphatase3 k57 kd57 phosphatase3 ERK-P ERK-P-phosphatase3 k58 kd58 ERK phosphatase3 ERK-P-phosphatase3 k57 kd57 ERKi-PP phosphatase3 ERKi-PP-phosphatase3 k56 kd56 ERKi-P phosphatase3 ERKi-PP-phosphatase3 k57 kd57 phosphatase3 ERKi-P ERKi-P-phosphatase3 k58 kd58 ERK phosphatase3 ERKi-P-phosphatase3 k57 kd57 ERK MEK-PP ERK-MEK-PP k52 kd44 MEK-PP ERK-P ERK-MEK-PP k53 kd53 MEK-PP ERK-P ERK-P-MEK-PP k52 kd44 ERK-PP MEK-PP ERK-P-MEK-PP k55 kd55 ERK MEKi-PP ERKi-MEKi-PP k52 kd44 ERKi-P MEKi-PP ERKi-MEKi-PP k53 kd53 MEKi-PP ERKi-P ERKi-P-MEKi-PP k52 kd44 ERKi-PP MEKi-PP ERKi-P-MEKi-PP k55 kd55 (EGF-EGFR*)2-GAP-Grb2 Prot (EGF-EGFR*)2-GAP-Grb2-Prot k4 kd4 (EGF-EGFRi*)2-GAP-Grb2 Proti (EGF-EGFR*)2-GAP-Grb2-Prot k5 kd5 EGFR 0 EGFRi k6 kd6 (EGF-EGFR*)2 0 (EGF-EGFRi*)2 k6 kd6 (EGF-EGFR*)2-GAP-Grb2 0 (EGF-EGFRi*)2-GAP-Grb2 k6 kd6 Proti 0 Prot k15 kd15 (EGF-EGFR*)2-GAP 0 (EGF-EGFRi*)2-GAP k6 kd6 (EGF-EGFR*)2-GAP-SHC 0 (EGF-EGFRi*)2-GAP-SHC k6 kd6 (EGF-EGFR*)2-GAP-SHC* 0 (EGF-EGFRi*)2-GAP-SHC* k6 kd6 (EGF-EGFR*)2-GAP-Grb2-Sos 0 (EGF-EGFRi*)2-GAP-Grb2-Sos k6 kd6 (EGF-EGFR*)2-GAP-Grb2-Sos Prot (EGF-EGFR*)2-GAP-Grb2-Sos-Prot k4 kd4 Proti (EGF-EGFRi*)2-GAP-Grb2-Sos (EGF-EGFR*)2-GAP-Grb2-Sos-Prot k5 kd5 (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP 0 (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP k6 kd6 (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP Prot (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot k4 kd4 Proti (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot k5 kd5 (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP 0 (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP k6 kd6 (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP Prot (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot k4 kd4 Proti (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot k5 kd5 (EGF-EGFR*)2-GAP-SHC*-Grb2 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2 k6 kd6 (EGF-EGFR*)2-GAP-SHC*-Grb2 Prot (EGF-EGFR*)2-GAP-SHC*-Grb2-Prot k4 kd4 Proti (EGF-EGFRi*)2-GAP-SHC*-Grb2 (EGF-EGFR*)2-GAP-SHC*-Grb2-Prot k5 kd5 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos k6 kd6 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos Prot (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Prot k4 kd4 Proti (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Prot k5 kd5 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP k6 kd6 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP Prot (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP-Prot k4 kd4 Proti (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP-Prot k5 kd5 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP k6 kd6 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP Prot (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP-Prot k4 kd4 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP Proti (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP-Prot k5 kd5 MEK-PP phosphatase2 MEK-PP-phosphatase2 k48 kd48 MEK-P phosphatase2 MEK-PP-phosphatase2 k49 kd49 phosphatase2 MEK-P MEK-P-phosphatase2 k50 kd50 MEK phosphatase2 MEK-P-phosphatase2 k49 kd49 MEKi-PP phosphatase2 MEKi-PP-phosphatase2 k48 kd48 MEKi-P phosphatase2 MEKi-PP-phosphatase2 k49 kd49 phosphatase2 MEKi-P MEKi-P-phosphatase2 k50 kd50 MEK phosphatase2 MEKi-P-phosphatase2 k49 kd49 ERK-PP (EGF-EGFR*)2-GAP-Grb2-Sos (EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP k126 kd126 ERKi-PP (EGF-EGFRi*)2-GAP-Grb2-Sos (EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP k126 kd126 ERK-PP (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-ERK-PP k126 kd126 ERKi-PP (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-ERKi-PP k126 kd126 ERK-PP Sos Sos-ERK-PP k126 kd126 ERKi-PP Sos Sos-ERKi-PP k126 kd126 ERK-PP 0 (EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP k127 kd127 ERK-PP 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-ERK-PP k127 kd127 ERK-PP Sosi Sos-ERK-PP k127 kd127 ERKi-PP 0 (EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP k127 kd127 ERKi-PP 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-ERKi-PP k127 kd127 ERKi-PP Sosi Sos-ERKi-PP k127 kd127 Phosphatase1 Raf* Raf*-phosphatase1 k42 kd42 Raf Phosphatase1 Raf*-phosphatase1 k43 kd43 Phosphatase1 Rafi* Rafi*-phosphatase1 k42 kd42 Raf Phosphatase1 Rafi*-phosphatase1 k43 kd43 MEK Raf* MEK-Raf* k44 kd52 MEK-P Raf* MEK-Raf* k45 kd45 MEK-P Raf* MEK-P-Raf* k44 kd52 MEK-PP Raf* MEK-P-Raf* k47 kd47 MEK Rafi* MEK-Rafi* k44 kd52 MEKi-P Rafi* MEK-Rafi* k45 kd45 Rafi* MEKi-P MEK-P-Rafi* k44 kd52 Rafi* MEKi-PP MEK-P-Rafi* k47 kd47 Ras-GTP Raf Raf-Ras-GTP k28 kd28 Ras-GTP* Raf* Raf-Ras-GTP k29 kd29 Ras-GTPi Raf Raf-Ras-GTPi k28 kd28 Ras-GTPi* Rafi* Raf-Ras-GTPi k29 kd29 Ras-GDP (EGF-EGFR*)2-GAP-Grb2-Sos (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP k18 kd18 Ras-GTP (EGF-EGFR*)2-GAP-Grb2-Sos (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP k19 kd19 Ras-GDP (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP k18 kd18 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos Ras-GTP (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP k19 kd19 Ras-GDP (EGF-EGFRi*)2-GAP-Grb2-Sos (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP k18 kd18 Ras-GTPi (EGF-EGFRi*)2-GAP-Grb2-Sos (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP k19 kd19 Ras-GDP (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP k18 kd18 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos Ras-GTPi (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP k19 kd19 (EGF-EGFRi*)2 GAP (EGF-EGFRi*)2-GAP k8 kd8 (EGF-EGFR*)2-GAP-Grb2-Sos Ras-GTP* (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP k20 kd20 (EGF-EGFR*)2-GAP-Grb2-Sos Ras-GDP (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP k21 kd21 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos Ras-GTP* (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP k20 kd20 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos Ras-GDP (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP k21 kd21 Ras-GTPi* (EGF-EGFRi*)2-GAP-Grb2-Sos (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP k20 kd20 (EGF-EGFRi*)2-GAP-Grb2-Sos Ras-GDP (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP k21 kd21 Ras-GTPi* (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP k20 kd20 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos Ras-GDP (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP k21 kd21 EGF EGFR EGF-EGFR k1 kd1 EGF-EGFR EGF-EGFR (EGF-EGFR)2 k2 kd2 (EGF-EGFR)2 0 (EGF-EGFR*)2 k3 kd3 EGFRi EGFi EGF-EGFRi k10b kd10 EGF-EGFRi EGF-EGFRi (EGF-EGFRi)2 k2 kd2 (EGF-EGFRi)2 0 (EGF-EGFRi*)2 k3 kd3 0 0 EGFR k13 kd13 (EGF-EGFR*)2 GAP (EGF-EGFR*)2-GAP k8 kd8 Grb2 (EGF-EGFR*)2-GAP (EGF-EGFR*)2-GAP-Grb2 k16 kd63 Sos (EGF-EGFR*)2-GAP-Grb2 (EGF-EGFR*)2-GAP-Grb2-Sos k17 kd17 Shc (EGF-EGFR*)2-GAP (EGF-EGFR*)2-GAP-SHC k22 kd22 (EGF-EGFR*)2-GAP-SHC 0 (EGF-EGFR*)2-GAP-SHC* k23 kd23 Grb2 (EGF-EGFR*)2-GAP-SHC* (EGF-EGFR*)2-GAP-SHC*-Grb2 k16 kd24 Sos (EGF-EGFR*)2-GAP-SHC*-Grb2 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos k25 kd25 (EGF-EGFR*)2-GAP Shc*-Grb2-Sos (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos k32 kd32 Shc* Grb2-Sos Shc*-Grb2-Sos k33 kd33 (EGF-EGFR*)2-GAP Grb2-Sos (EGF-EGFR*)2-GAP-Grb2-Sos k34 kd34 Sos Grb2 Grb2-Sos k35 kd35 Shc* 0 Shc k36 kd36 (EGF-EGFR*)2-GAP Shc* (EGF-EGFR*)2-GAP-SHC* k37 kd37 Grb2 Shc* Shc*-Grb2 k16 kd24 (EGF-EGFR*)2-GAP Shc*-Grb2 (EGF-EGFR*)2-GAP-SHC*-Grb2 k37 kd37 Sos Shc*-Grb2 Shc*-Grb2-Sos k40 kd40 Grb2-Sos (EGF-EGFR*)2-GAP-SHC* (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos k41 kd41 (EGF-EGFRi*)2-GAP Grb2 (EGF-EGFRi*)2-GAP-Grb2 k16 kd63 Sos (EGF-EGFRi*)2-GAP-Grb2 (EGF-EGFRi*)2-GAP-Grb2-Sos k17 kd17 Shc (EGF-EGFRi*)2-GAP (EGF-EGFRi*)2-GAP-SHC k22 kd22 (EGF-EGFRi*)2-GAP-SHC 0 (EGF-EGFRi*)2-GAP-SHC* k23 kd23 Grb2 (EGF-EGFRi*)2-GAP-SHC* (EGF-EGFRi*)2-GAP-SHC*-Grb2 k16 kd24 Sos (EGF-EGFRi*)2-GAP-SHC*-Grb2 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos k25 kd25 (EGF-EGFRi*)2-GAP Shc*-Grb2-Sos (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos k32 kd32 (EGF-EGFRi*)2-GAP Grb2-Sos (EGF-EGFRi*)2-GAP-Grb2-Sos k34 kd34 (EGF-EGFRi*)2-GAP Shc* (EGF-EGFRi*)2-GAP-SHC* k37 kd37 (EGF-EGFRi*)2-GAP Shc*-Grb2 (EGF-EGFRi*)2-GAP-SHC*-Grb2 k37 kd37 Grb2-Sos (EGF-EGFRi*)2-GAP-SHC* (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos k41 kd41 GAP Ras-GTP GAP-Ras-GTP k300 kd20 GAP Ras-GDP GAP-Ras-GTP 0 kd21 GAP Ras-GTPi GAP-Ras-GTPi k300 kd20 GAP Ras-GDP GAP-Ras-GTPi 0 kd21 GAP Ras-GTP* GAP-Ras-GTP* k300 kd20 GAP Ras-GDP GAP-Ras-GTP* 0 kd21 GAP Ras-GTPi* GAP-Ras-GTPi* k300 kd20 GAP Ras-GDP GAP-Ras-GTPi* 0 kd21 Sosi Ras-GDP Sos k300 0