Reactant1 Reactant2 Product kForward kReverse Comment E S E:S k1on k1off E_+_S_<->_ES E M E:S 0 k1cat E_+_M_<-_ES E M E:M k2on k2off E_+_M_<->_EM E D E:M 0 k2cat E_+_D_<-_EM P D P:D k3on k3off P_+_D_<->_PD P M P:D 0 k3cat P_+_M_<->_PD P M P:M k4on k4off P_+_D_<->_PD P S P:M 0 k4cat P_+_M_<->_PD 0 0 P ksynth 0 0 0 S ksynth 0